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- Ångström-Resolution Fluorescence Microscopy
A breakthrough in fluorescence microscopy has been achieved by the research group of Ralf Jungmann at the Max Planck Institute of Biochemistry (MPIB) and Ludwig-Maximilians-Universität (LMU) Munich...
- New software improves data-independent acquisition proteomics
Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteo... - New microscopy analysis allows discovery of central adhesion complex
Cells of organisms are organized in subcellular compartments that consist of many individual molecules. How these single proteins are organized on the molecular level remains unclear, because suita...
- Nuclear pores in their natural context
The architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies, and increases our understanding of crucial processes of life. Scientists from t... - In the right place at the right time - activation chain of protein degradation deciphered
Proteins are molecular work horses in the cell that perform specific tasks, but it is essential that the timing of protein activities is exquisitely controlled. When proteins have fulfilled their t...
- 10-times faster image Acqusition Super-Resolution Microscopy at speed
Recent advances in fluorescence microscopy allow researchers to study biological processes below the classical diffraction limit of light. Ralf Jungmann, research group leader at the Max Planck Ins... - Learning from spectral experience
The protein composition of cells depends on the cells' function and current condition. Mass spectrometry (MS) can determine the identity and quantity of the proteins found in a sample. However, the...
- Chromosome segregation in meiosis
Once together, never apart - isn't that how the saying goes? Not so in meiosis, the special type of cell division in which gametes, sperm and egg cells are formed. At the start of meiosis the ring-...
- Immunotherapy for cancer: identifying suitable target antigens by mass spectrometry
New cancer therapies harness the immune system to fight tumors. One of the main principles behind these therapies is to find out precisely which molecules on cancer cells trigger an immune response... - Scientists use neutrons to understand the secrets of extremophile bacteria
Microorganisms represent the most numerous life on earth and the understanding of how they behave is integral to our own survival and well-being. Microbial life has an amazing flexibility for adapt... - Novel EU-funded collaborative proteomics project to bring proteomics to clinical application
Novel proteomic technologies that are so robust and powerful that they can be used in every biological laboratory and in every clinic are expected as results of the currently starting research cons...
- New insights into the structure of the Golgi apparatus by cryo-electron tomography
The Golgi apparatus serves as a cellular post office, sending the cell's many proteins to their correct destinations. In order to mark and sort the proteins, the Golgi has an elaborate architecture... - The Macromolecular Shredder for RNA in the Cell Nucleus
Scientists of the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, have shown how the nuclear compartment of the cell uses a specific version of the RNA exosome, a m... - DNA repair toolbox examined using mass spectrometry
Various repair mechanisms help our cells to revert continuous damage to their DNA. If they fail, mutations accumulate in the genome that can lead to devastating diseases. DNA repair defects underli... - Researchers observe protein degradation in intact brain cells
Neurodegenerative diseases like Alzheimer's, Huntington's or Parkinson's are caused by defect and aggregated proteins accumulating in brain nerve cells that are thereby paralyzed or even killed. In... - Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography
Photosynthesis sustains most of the life on our planet. It harvests energy from sunlight, while generating oxygen and removing carbon dioxide from the atmosphere. The process takes place in the chl...
- Important mechanism of protein folding elucidated
Proteins are responsible for nearly every essential process of life. Their form and structure (or their "fold") are of crucial importance for their functionality. Scientists at the Max Planck Insti...
- A Macromolecular Shredder for RNA - Structure of the machinery for RNA disposal unraveled
Much in the same way as we use shredders to destroy documents that are no longer useful or that contain potentially damaging information, cells use molecular machines to degrade unwanted or defecti... - What Holds Chromosomes Together - Scientists Elucidate the Structure of DNA-Packaging
To ensure that the genetic material is equally and accurately distributed to the two daughter cells during cell division, the DNA fibers must have an ordered structure and be closely packed. At the... - New Insights into Cell Division - Max Planck Researchers Develop Minimal System
All living organisms consist of cells that have arisen from other living cells by the process of cell division. However, it is not yet fully understood just how this important process takes place. ...
- Cloud research at extreme altitudes
Polar stratospheric clouds are crucially involved in the formation of the ozone hole. In order to explore their development, measurements at extreme altitudes are needed. This is what researchers f...
- British chemist recognized as leader in mass spectrometry
The European Molecular Biology Organization (EMBO) and the Federation of European Biochemical Societies (FEBS) announce Carol V. Robinson, Professor of Chemistry at the University of Oxford, UK, as...
- Human protein factories in 3D - Insights into the interior of human cells at the nano level
Due to cell-biological research, it is already known which components of the cell are responsible for the production of proteins. But so far it has not been explored in detail how these protein fac... - Genetic Code 2.0 - Novel Artificial Proteins for Industry and Science
The creation of synthetic proteins plays an important role for economy and science. By the integration of artificial amino acids in proteins (genetic code engineering), their already existing quali... - Scientists develop new method to identify glycosylated proteins
Various processes in our body are controlled by subsequent changes of proteins. Therefore, the identification of such modifications is essential for the further exploration of our organism. Now, sc...