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- Starting point for the development of new active substances against the hospital germ
When the hospital germ Pseudomonas aeruginosa infects the body, it uses the sugar-binding protein LecA to attach itself to human cells, invade them, and form so-called biofilms. LecA thus plays a c... - Multi-resistant bacteria: development of new antibiotics
The German Research Foundation (DFG) and the French Agence National de la Recherche (ANR) are now funding the project "Characterization of novel natural product binding sites in the DNA gyrase of m... - Game-changer in the fight against multidrug-resistant pathogens
The development and spread of antibiotic resistance represents one of the greatest threats to global health. To overcome these resistances, drugs with novel mode of action are urgently needed. ... - New avenues for the treatment of multi-resistant pathogens
Antibiotics are a double-edged sword - they should be as toxic as possible to pathogenic bacteria while being harmless to the cells of the human body. An international research team led by the Helm...
- Activating the hidden pharmaceutical potential of bacteria
Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in t...
- Promising active ingredient to combat multi-resistant bacteria
The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. These so-called lectins are therefo...
- Optimized drug candidate against multi-resistant bacteria and parasites
The development of new active substances against pathogenic bacteria, parasites, fungi and viruses is gaining importance, as established antiinfectives are becoming increasingly ineffective due to ...
- Drug candidates against hospital germs
The increasing spread of resistant germs means that formerly highly effective antibiotics are often not successful anymore in treating infectious diseases. To counteract this development, the team ...