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- Starting point for the development of new active substances against the hospital germ
When the hospital germ Pseudomonas aeruginosa infects the body, it uses the sugar-binding protein LecA to attach itself to human cells, invade them, and form so-called biofilms. LecA thus plays a c... - Use of innovative RNA technology to intervene in phage reproduction
Phages are viruses that infect bacteria. Using phages therapeutically could be very useful in fighting antibiotic-resistant pathogens, but the molecular interactions between phages and host bacteri... - ERC grant for research into bacteriophages
In the fight against multiresistant bacteria, bacteriophages-the natural enemies of bacteria-are attracting increasing research interest. However, the targeted therapeutic application of these "bac... - Game-changer in the fight against multidrug-resistant pathogens
The development and spread of antibiotic resistance represents one of the greatest threats to global health. To overcome these resistances, drugs with novel mode of action are urgently needed. ... - New avenues for the treatment of multi-resistant pathogens
Antibiotics are a double-edged sword - they should be as toxic as possible to pathogenic bacteria while being harmless to the cells of the human body. An international research team led by the Helm...
- Activating the hidden pharmaceutical potential of bacteria
Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in t...
- Promising active ingredient to combat multi-resistant bacteria
The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. These so-called lectins are therefo... - Interrogating disease progression and cell processes in vivo and non-invasively
Do we simply ingest a diagnostic probiotic based on programmed ribonucleic acids to analyze the intestinal health from individual cells in the future? Researchers at the Helmholtz Institute for RNA... - New type of CRISPR gene scissors could advance molecular biology diagnostics
It is an unexpected discovery by scientists at the Helmholtz Institute Würzburg in cooperation with Benson Hill, Inc. (Missouri) and Utah State University in the U.S.: They have found a nuclease, w...
- Optimized drug candidate against multi-resistant bacteria and parasites
The development of new active substances against pathogenic bacteria, parasites, fungi and viruses is gaining importance, as established antiinfectives are becoming increasingly ineffective due to ... - New CRISPR Element Regulates Viral Defense
Researchers from Würzburg, Freiburg and Leipzig discover a mechanism for prioritizing the immune response in bacteria. What tasks need to be done today, and which is the most urgent? People hav...
- Drug candidates against hospital germs
The increasing spread of resistant germs means that formerly highly effective antibiotics are often not successful anymore in treating infectious diseases. To counteract this development, the team ... - On the leap to new antiviral agents
The Federal Agency for Disruptive Innovation (SPRIND) has announced the participants of the first SPRIND Challenge "A Quantum Leap for New Antiviral Agents". From 45 applications from Germany and E...
- Lung mucus gel scaffold prevents nanoparticles from getting through
Scientists at the Saarland University and the Helmholtz Centre for Infection Research (HZI) unraveled lung mucus's physical properties: They discovered that a rigid gel scaffold in lung mucus separ...