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08/09/2022

08/04/2022

New assessment of the flavouring substance acetaldehyde

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Acetaldehyde occurs naturally in many foods and is also used as a flavouring substance due to its fruity aroma. The Senate Commission on the Food Safety (German SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft-DFG) has reviewed the current data situation for assessing the health risk of the use of acetaldehyde as a flavouring substance.

In view of numerous data gaps that need to be closed for a complete risk assessment and the resulting uncertainties, the commission concludes that there are doubts about the safety of acetaldehyde as a flavouring substance.

In the opinion of the SKLM, the deliberate addition of acetaldehyde as a flavouring substance should therefore be re-evaluated for reasons of precautionary consumer protection.

Acetaldehyde occurs naturally in numerous foods, for example in coffee, bread, fruits or yoghurt. Due to its fruity aroma, acetaldehyde is also used as a flavouring agent in or on food. Acetaldehyde enters alcoholic beverages as a by-product of alcoholic fermentation. In addition, acetaldehyde is formed in the human body during the degradation of ethanol and during certain metabolic processes.

The SKLM reviewed the current data on the origin, occurrence, intake levels and cancer risk of acetaldehyde as a flavouring substance and concluded that the data available is very limited. Currently it is not possible to reliably assess the use of acetaldehyde as a flavouring substance.
Data on carcinogenic effects and systematic analyses are lacking

The question whether acetaldehyde has a genotoxic and mutagenic effect after ingestion via food cannot be answered conclusively at present. For example, such an effect on tissues exposed directly to acetaldehyde, e.g., oral cavity or oesophagus, cannot be completely ruled out.

Additionally, there are no systematic data on acetaldehyde levels in food. Furthermore, it is not possible to distinguish on the basis of analytical data whether the levels measured so far in foodstuffs are due to the use as a flavouring substance, to the transition from packaging materials or to a natural occurrence. It is also not possible to estimate quantities based on the declaration of the foodstuffs, as acetaldehyde falls under the ingredient Flavor as a collective term and does not have to be labelled separately.

Further research needed for comprehensive risk assessment

"More research is needed to be able to carry out a reliable and comprehensive risk assessment. We need standardised analytical methods to perform systematic chemical analyses of acetaldehyde levels in major food groups. Likewise, studies with specific biomarkers are necessary to monitor exposure to acetaldehyde from foodstuffs. These biomarkers should be used to investigate whether there are local effects in the upper digestive tract," explains Prof. Jan Hengstler, chairman of the SKLM and scientific director of the Leibniz Research Centre for Working Environments and Human Factors in Dortmund (IfADo).

Due to the gaps in knowledge and the resulting uncertainties, as well as the concerns about a possible mutagenic effect of orally ingested acetaldehyde, the SKLM concludes that there are doubts about the safety of acetaldehyde as a flavouring substance. "The SKLM agreed that the targeted addition of acetaldehyde as a flavouring substance should be re-evaluated for reasons of precautionary consumer protection", Jan Hengstler summarises.

» Original publication

Source: IfADo - Leibniz Research Centre for Working Environment and Human Factors