Senior Scientist Protein Modifications (m/f/d)

  • Independently develops solutions and strategies within own expertise while using breadth of knowledge of other disciplines
  • Ensures the appropriate conduct of studies, leads the interpretation of study results, and prepares study reports suitable for internal or regulatory use
  • Lead protein-protein interactions projects to understand the mechanism of action (MOA) for disease associated mutations leading to initiation of drug discovery programs in alignment with Takeda Drug Discovery Unit priorities
  • Develop in vitro/ex vivo assays to characterize proteome-wide protein-protein interactions and protein secondary modifications
  • Design and execute in vitro/ex vivo experiments independently to determine the relevant functional readouts associated with modulation of the target functions using molecular, biochemical or enzymatic assays
  • Generate, analyze and interpret data in appropriate scientific context and present data and project updates at department and cross-functional meetings
  • PhD degree in a scientific discipline with 5+ years experience, or
  • MS with 10+ years experience, or
  • BS with 12+ years experience in gene regulation, rare diseases, inflammatory diseases, neuroscience, or related field.
  • Minimum of 2-4 years of drug discovery industry, project leadership experience is required
  • Protein biochemistry background and expertise is highly desired
  • Extensive experience in Molecular biology, fusion-protein library construction, assay development, primary cell isolation and culture, transfection/viral transduction, siRNA knockdown, ELISA, WB, Co-IP, and immunohistochemistry is required

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Dan Diego [USA]