Associate Scientist I/II, Conjugation Chemist (m/f/d)

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision
  • Optimization and validation of conjugation protocols and formulation buffers
  • Optimization of automated techniques for ADC synthesis and purification
  • BS or MS degree with 0-3+ (BS) or 0+ (MS) years of experience in Analytical Chemistry,Biochemistry, Chemistry or other relevant discipline
  • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred
  • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired
  • Hand on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF)

» Job description

AbbVie Inc.
Worcester, Massachusetts [USA]