Head Biochemistry and Structural Biology Lab (m/f/d)
Your Profile:
- A PhD in biochemistry or structural biology or a closely related discipline with a minimum of 5 years' work experience in an industrial drug discovery setting
- Experience and proven track record in the development and use of biochemical assays to study different molecular target classes (e.g. ELISA assays, biomarker detection, protein purification, protein-protein or protein-ligand interactions, protein turn over, enzymatic assays, capillary-based immunoassays and automated Western blot analysis)
- And/or experience in structural biology and biophysical techniques (e.g. surface plasmon resonance, microScale Thermophoresis, Spectral Shift, differential scanning fluorimetry, dynamic Light Scattering, calorimetry, x-ray crystallographic analysis, electron cryo microscopy)
- Experience with RNA-modulating therapies (ASO, siRNA) incl. targeted delivery is an advantage.
- Ability to set up novel techniques in a result-oriented manner
- A passion for investigating molecular mechanisms and for exploring targets and a good understanding on how targets/pathways can be modulated in pain, neuroscience in general and adjacent disease areas.
- A deep knowledge of human chronic pain disorders is an advantage.
- Excellent mathematical skills and data analysis capabilities and a drive for data quality and high-quality documentation
- Experience and motivation to manage labs
- Pragmatic, optimistic, problem-solving attitude with natural curiosity; someone who will reach out proactively, internally and externally, to source alternative solutions
- Excellent organizational and communication skills with a high level of team spirit and pro-activity
- Ability to challenge the status quo and to embrace change with an open mind
Your Tasks:
- Generate impactful human cell-based and other in vitro biochemistry and structural biology data to support our small molecule and genetic medicine projects
- Explore target mechanisms and propose and evaluate novel targets
- Propose, manage and drive internal programmes
- Represent the Biochemistry and Structural Biology Lab in cross-disciplinary project teams and in external collaborations with academic, biotechs and CROs
- Ensure high quality experimentation (internal and external), analysis and data management
- Use scientific expertise to guide and develop team colleagues in their assignments
- Foster open and clear communication within the team and across different functions
Employer:
Grünenthal Group
Location:
52078 Aachen
Temporary:
No
Type:
Full-time