Analytik NEWS
Online Laboratory Magazine
02/04/2023

Senior Scientist - RNA Therapeutics (m/f/d)

Share:

Basic qualifications:

  • Doctorate degree and 2 years of siRNA and/or mRNA design, preparation, analysis, characterization, or purification, pharmaceutical research experience, or equivalent experience OR
  • Master's degree and 5 years of siRNA and/or mRNA design, preparation, analysis, characterization, or purification, pharmaceutical research experience, or equivalent experience OR
  • Bachelor's degree and 7 years of siRNA and/or mRNA experience, or equivalent experience with additional RNA synthesis and analytics or pharmaceutical research experience

Preferred qualifications:

  • Doctorate degree in Chemistry, Analytical Chemistry, Chemical
  • Engineering, Biochemistry, Molecular Biology or a similar field
  • Candidates should have a strong background (2+ years) in mRNA characterization including expertise in traditional large molecule analytical techniques
  • Experience in lab scale analysis of IVT mRNA transcripts and mRNA-LNP formulations
  • Proficient skills in preparation, purification and analytical characterization of RNA modalities

What you will do:

  • The Senior Scientist will work as part of the RNA Therapeutics team responsible for developing RNA (RNAi and mRNA) design, preparation, characterization, and testing strategies.
  • Develop strategies for the cell type-specific delivery of siRNA outside of the liver.
  • Design and optimize processes for the analysis of mRNA in vitro transcription (IVT) products, including devising mRNA IVT by-product analysis and purification strategies.
  • Responsible for characterization of RNA post encapsulation in lipid nanoparticles (LNPs).
  • Additional responsibilities include but are not limited to: Implementing creative scientific strategies to address therapeutic RNA challenges through conducting laboratory experiments, working closely with other researchers to influence team direction and advance programs, communicating progress and strategy in various forums, and preparing technical documents.
  • Interact directly with researchers within RNA Therapeutics, the Research Biomics Group, and multiple Therapeutic Areas to optimize mRNA translation through transcript design, modification, production and LNP-mediated delivery.
  • Serve as a scientific resource to the department who will champion new technologies/ideas to enhance capabilities.
  • The Senior Scientist may directly or indirectly lead research associates within a collaborative environment and be responsible for technical training and professional development.


» Job description


Employer:
Amgen Ltd.
Location:
Thousand Oaks, Kalifornien [USA]
Temporary:
No
Part-time:
No