Analytik NEWS
Online Laboratory Magazine
10/03/2022

Scientist Early-Stage Formulation Process Development (m/f/d)

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What you have to offer:

  • Doctoral degree in pharmaceutical or other natural sciences (e.g. chemistry, biology) as well as a sound knowledge on factors affecting the stability of RNA nanoparticles for various storage conditions such as refrigerated or frozen conditions
  • Fundamental understanding on the manufacturing process of RNA nanoparticles with sound knowledge on the inclusion of auxillary components that can influence the stability and ADME, mechanistic understanding on material properties is a plus
  • Profound knowledge on physicochemical characterization of lipid and polymer based nanoparticle preparations (e.g. gel electrophoresis, SEC, DLS, zeta potential, fluorescence spectroscopy), insights on extended characterization techniques such as CD, SAXS, AF4, Cryo-TEM is a plus
  • Conscientious and careful working methods as well as organizational skills, paired with good English skills (written and spoken)

Your main responsibilities are:

  • Design and development of the GMP compatible manufacturing process for mRNA loaded lipid nanoparticles
  • Generate fundamental understanding on the manufacturing process of mRNA loaded lipid nanoparticles
  • Characterization and assessment of colloidal and chemical stability assessment of nanoformulations as a function of ageing
  • Data processing, evaluation, documentation of experiments, and writing of reports
  • Responsibility for instruments, laboratory management, and supervision of Student Assistants and Research Associate


» Job description


Employer:
BioNTech AG
Location:
55131 Mainz
Temporary:
No
Part-time:
No