Analytik NEWS
Online Laboratory Magazine
10/01/2022

Scientist I, Investigative Toxicology (m/f/d)

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Minimum Requirements / Qualifications:

  • PhD in biology, pharmacology, toxicology or a related discipline with PostDoc experience.
  • Experience with conventional and advanced cell culture approaches with cell lines, primary cells, and iPSC cells. Experience with 3D cell-culture and cell based assays is highly desirable.
  • Experience running routine immunoassays including flow cytometry, ELISA, Luminex, and MSD.
  • Experience in assays related to liver safety biomarkers, transporters, and P450 enzymes is desired.
  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
  • Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
  • Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker
  • development and application, and for de-risking drug candidates.
  • Experience with organ systems in addition to liver such as cardiovascular, GI, and immune systems is highly desired
  • Experience with in vitro methods to assess the safety and efficacy of non-viral gene therapies is desired.
  • Strong interpersonal and organizational skills
  • Excellent oral and written communication skills

Accountabilities:

  • Lead toxicological investigations to detect & de-risk toxicities in drug discovery and development using in vitro and in vivo data.
  • Use cutting edge cell culture and organ-on-a-chip technologies to help make the next generation of gene and cell therapies.
  • Probe molecular and cellular mechanisms of toxicity to determine drivers of liver, lung and cardiovascular toxicities and guide drug projects to make safer medicines using your experience, in-house, and literature data.


» Job description


Employer:
Takeda
Location:
Boston, MA [Vereinigte Staaten]
Temporary:
No
Part-time:
No