Analytik NEWS
Online Laboratory Magazine
06/28/2022

Scientist III/IV, Molecular Pathology (m/f/d)

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Scientist III Requirements:

  • Bachelor's Degree from an accredited institution with 7+ years of experience in a relevant scientific discipline; or Master's Degree from an accredited institution with six-plus (3+) years of experience in a relevant scientific discipline

Scientist IV Requirements:

  • Bachelor's Degree from an accredited institution with 10+ years of experience in a relevant scientific discipline; or Master's Degree from an accredited institution with 6+ years of experience in a relevant scientific discipline

Other Requirements:

  • Hands on experience in assay development and optimization, data analysis and interpretation.
  • Knowledge and experience in the principles and approaches for development of Immunohistochemistry (IHC), in situ hybridization (ISH) assays
  • Knowledge and experience in the principles and approaches for development of antibody reagent characterization, cataloging
  • Laboratory management experience

Preferred Experience:

  • Familiarity or experience with Retrogenix Cell Microarray Technology a plus. Work with our Discovery organization to support the selection of lead molecules or the characterization off-target toxicities within Development.
  • Digital imaging experience with commercial image analysis software such as Definiens, Visiopharm, HALO, or other platforms. The successful candidate will support image analysis by generating scanned whole slide images of tissues labeled with various molecular pathology techniques (IHC, ISH, IF) to quantify cellular and tissue morphologic endpoints. Projects will be conducted in collaboration with a software programmer to run machine learning and deep learning algorithms.

Duties & Responsibilities:

  • Coordinate and conduct target tissue distribution studies - Oversee ordering and validation of antibodies and control reagents; optimize and troubleshoot IHC and ISH assays as needed, including chromogenic and fluorogenic formats; work with project pathologists to characterize target expression; and write methods for study reports.
  • Develop and transfer methods for tissue cross-reactivity studies - Ensure all needed reagents, tissues, and control materials are ordered and received in a timely fashion; oversee labeling and characterization of reagents as needed; conduct IHC assays and confirm that methods are optimized and fit-for-purpose; review immunolabeling with project pathologists; and write method development reports for transfer to Contract Research Organizations.
  • Develop and implement new assays and biomarkers -- Develop, conduct, and optimize novel tissue -based assays; support use of enhanced safety or mechanistic endpoints in NDS non-clinical safety evaluations; and propose new assays, techniques, or approaches based on current information.
  • Document work activities and study records completely and accurately -- Maintain records for all laboratory work in accordance with study protocols by following applicable company policies, using current forms and procedures, and making all entries legibly, correctly and contemporaneously; and perform all work safely and in compliance with all applicable regulations, standard operating procedures, company policies, safety training and procedures.
  • Initiate and complete routine laboratory procedures in an independent and efficient manner, with minimal supervision, and independently operate and manage laboratory equipment.
  • Demonstrate technical ability to assist in the design, execution, and troubleshooting of non-routine experiments with limited supervision.
  • Apply basic scientific principles with minimal guidance; performs literature searches and extracts relevant information from published protocols.
  • Demonstrate the ability to interpret outcome of experiments and to propose appropriate follow-up work.


» Job description


Employer:
Boehringer Ingelheim Pharma GmbH & Co. KG
Location:
CT, Richfield [Vereinigte Staaten]
Temporary:
No
Part-time:
No