Scientist- Microbiology, Systems Biology, Functional Omics (m/f/d)
- PhD/Doktorgrad or equivalent in natural sciences (Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields)
- Experience of designing and running experiments with microbial cultures (bacteria and/or fungi) in the laboratory
- Hands-on experience with key biochemical and molecular biological methods
- Experience with systems biology projects, high-throughput methodologies
- Experience with analytical and omics methods (LC-MS, NGS)
- Basic ability to analyse data in R or Python
- Good communication skills for collaborative work
- Any of the following will be a plus:
- Proficiency in data analysis using R
- Interest in multispecies communities, host-pathogen interactions, or related topics
- Working language is English. Applicants with multidisciplinary background or unusual career paths are also encouraged to apply.
ResponsibilitiesWe are looking for a highly enthusiastic postdoctoral scientist to investigate the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance (AMR), with particular focus on the multi-drug resistant bacterium Pseudomonas aeruginosa (PA) and the opportunistic fungal pathogen Candida albicans (CA). This position will be formally based at the Charité in Berlin, but will conduct part of the project at the University of Oxford.
Your main tasks will be:
- Adapting existing and developing improved experimental protocols for the high-throughput analysis of AMR in a CA-PA co-infection model;
- Determining the underlying mechanisms that alter stress tolerance in a CA-PA co-infection model;
- Performing Adaptive Laboratory Evolution (ALE) and high-throughput proteomics experiments to monitor the emergence of tolerance and resistance in CA-PA communities;
- Identifying synergistic mechanisms that enable co-infecting pathogens to establish persistent communities and lead to worse patient outcomes;
- Promoting and fostering awareness about co-infections and their role in AMR emergence; - Lead and support the preparation of scientific reports and journal articles.
- Lead and support the preparation of scientific reports and journal articles.
- State-of-the-art research equipment and highly international and collaborative environments both at the Charité - Universitätsmedizin Berlin and University of Oxford;
Extended stays at each academic institution;
- Opportunity to work in close contact with other basic- and clinical-research groups at Charité in the heart of Germany's vibrant capital;
- Opportunity to work in close contact with other research groups within the Department of Zoology at the University of Oxford, one of the world's leading research universities;
- Potential to lead multiple projects and a high degree of academic freedom
Charité - Universitätsmedizin Berlin