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Senior Scientist DMPK (m/f/d)

  • PhD in pharmacy, biochemistry, chemistry or related fields with relevant DMPK experience in the pharmaceutical, biotech industry or at CROs (at least 5 years)
  • Profound knowledge of the drug discovery and development process and how DMPK studies contribute to that
  • Proficient in Phoenix WinNonlin and ideally experienced with simulation software / tools such as SimCYP or GastroPlus
  • Providing PK consultancy and guiding pharmaceutical clients throughout different phases of the R&D value chain
  • Supporting the generation of development plans for new chemical entities (NCEs) and other modalities such as Antibody Drug Conjugates (ADCs) or PROTACs
  • Acting as DMPK representative in client's project teams, designing and commissioning PK experiments to support compound optimization, drug candidate selection and / or subsequent development (interface to operational teams in Grafing and at other sites)
  • Acting as project manager and client's contact for phase projects (e.g., from candidate selection to First in Human trials), comprising oversight of in vitro and in vivo DMPK, bioanalytical, and toxicokinetic studies performed by NUVISAN
  • Writing DMPK sections of regulatory dossiers (IND, IMPD) and Briefing Books
  • Conducting non-compartmental analyses (NCA) for PK and toxicokinetic studies
  • Establishing internal PK/PD modeling and simulation capabilities, exploring the PK/PD relationship in pre-clinical models and predicting human PK parameters, dose and dosing regimens
  • Providing scientific input to the design of in vitro and / or in vivo DMPK studies
  • Following literature related to DMPK and maintaining awareness of the latest developments in that area
  • Supporting the strategic vision of the leadership team as well as the expansion of NUVISAN's service portfolio and capabilities

» Job description

85567 Grafing near Munich