Postdoctoral Fellow (m/f/d)
- A background in molecular and cell biology
- Previous experience with optogenetics, microscopy techniques or 2D/3D cell culture will be a distinct advantage, along with competencies in computer-based quantification and analysis of experimental images (Matlab, ImageJ/FiJi or similar)
The successful candidate will be based at the EMBL-Heidelberg in the Leptin Lab. The first stage of the project will focus on engineering an in vitro optogenetic cellular model that can selectively regulate the mechanics of the cellular cortex and its subdomains. Mechanical features of the optogenetic cell model will subsequently be tested at the TU Eindhoven in the Conte Lab.
The in vitro experimental methods involved in this inquiry will include a wide spectrum of molecular and cell biology techniques for the (optogenetical) manipulation of both cellular genotype and phenotype (e.g. plasmid engineering transfection / transduction, selection etc.) advanced microscopy (including epifluorescence, phase contrast and confocal microscopy). To create the new cellular model, the candidate will build on established experimental protocols and optogenetic constructs as well as create new ones.