Senior Scientist, Analytical Characterization, Protein Analytics (m/w/d)

  • Independently develop and apply state of the art mass spectrometry, capillary electrophoresis, and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities
  • Identify post-translational modifications and characterize structure-activity relationships of products under development
  • Provide technical support and oversight for QC testing occurring at internal and external GMP testing laboratories
  • Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs)
  • Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods
  • Participate in analytical investigations and analytical trouble shooting efforts
  • Serve as an analytical lead for internal AbbVie programs
  • Represent the Protein Analytical Chemistry Group as a subject matter expert on cross functional teams
  • Conducting experiments independently, communicating results at team meetings, authoring reports and contributing to AbbVie filings
  • Bachelors, Masters or PhD Degree in Biochemistry, Chemistry, Analytical Chemistry, Biophysics (or related discipline) and 10-12+ (BS), 8-10+ (MS) or 0-4+ (PhD) years of experience in industry or academia
  • Strong background in biophysics and ability to develop enzyme assays; troubleshoot and plot data is preferred
  • Experience with protein mass spectrometry, LC-MS, UPLC, HPLC, capillary electrophoresis, glycoprotein and mAb characterization and bioinformatics
  • Experience with Circular Dichroism (CD), Differential Scanning Calorimetry (DSC), Analytical Ultracentrifugation (AUC), and other biophysical methods is a plus
  • Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is desired

» Job description

AbbVie Inc.
Worcester, Massachusetts [USA]