Conjugation Chemist (m/w/d)

  • Synthesis, purification and characterization of ADCs on mg to gram scale
  • Development and optimization of conjugation protocols utilizing novel chemistries and technologies
  • Demonstrating automated techniques for ADC synthesis and purification
  • Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie
  • Bachelors, Masters or Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology or closely related field with typically 7-10+(BS), 5-8+(MS), 0+(Ph.D) years of experience; Industry experience preferred
  • Hands-on experience with generation and characterization of antibody drug conjugates; Preferably in the area of biotherapeutics
  • Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography-mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF)
  • Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography
  • Experience with GE AKTA FPLC and unicorn software preferred

» Job description

AbbVie Inc.
Worcester, Massachusetts [USA]